Fig. 6.

Anticonvulsant concentrations of PQQ do not interfere with NMDAR-dependent synaptic plasticity. LTP of the CA1 field EPSP evoked by Schaffer collateral stimulation was induced by tetanic stimulation in control slices (n = 4) and in slices maintained in 200 μm PQQ (n= 4) for 30 min before tetanus and for the duration of recording.A, The superimposed traces show averaged field EPSPs (5 events) before and after tetanus in a representative slice recorded in the presence of PQQ. B, The summary graph shows the mean increase in EPSP slope as a function of time from the tetanus for the two conditions. The magnitude of LTP was not statistically different in the presence versus the absence of PQQ (two-way repeated measures ANOVA with post hoccomparison).