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Systemic pretreatment with PQQ significantly attenuated seizures induced by PTZ or BMI. A, B, The bar graphs show the mean duration of PTZ-induced (A) and BMI-induced (B) seizures for control (HCO3 vehicle-treated) and PQQ-treated groups. The durations of PTZ- and BMI-induced generalized seizures were significantly decreased in PQQ-treated animals.
