Table 4.
Thyroid status | Brain region | NSP mRNA | Oct-1 mRNA |
---|---|---|---|
Control | Cortex | 100.00 ± 2.44 (5) | 100.00 ± 0.45 (5) |
T3 | 99.12 ± 1.85 (6) | 92.70 ± 1.58 (6)** | |
MMI + PTU | 104.00 ± 2.58 (6) | 99.45 ± 0.77 (6) | |
MMI + PTU + T3 | 101.01 ± 1.22 (6) | 95.71 ± 1.40 (6)* | |
Control | Dentate gyrus | 100.00 ± 1.73 (5) | 100.00 ± 1.66 (5) |
T3 | 98.51 ± 0.71 (5) | 96.01 ± 1.48 (6)* | |
MMI + PTU | 105.09 ± 1.08 (5)* | 101.09 ± 0.52 (6) | |
MMI + PTU + T3 | 100.01 ± 1.27 (6) | 95.99 ± 0.81 (6)* | |
Control | CA14-a | 100.00 ± 1.09 (4) | 100.00 ± 1.55 (4) |
T3 | 105.27 ± 1.75 (6) | 97.94 ± 1.57 (6) | |
MMI + PTU | 108.80 ± 2.08 (6)* | 101.97 ± 1.11 (6) | |
MMI + PTU + T3 | 104.17 ± 1.27 (6) | 97.42 ± 1.13 (6) | |
Control | CA24-a | 100.00 ± .67 (3) | 100.00 ± 1.10 (5) |
T3 | 101.36 ± 1.65 (6) | 95.82 ± 0.98 (6)* | |
MMI + PTU | 105.93 ± 1.54 (5) | 99.37 ± 0.20 (4) | |
MMI + PTU + T3 | 100.20 ± 1.15 (6) | 95.11 ± 10.4 (6)** | |
Control | CA34-a | 100.00 ± 0.85 (4) | 100.00 ± 0.26 (5) |
T3 | 100.64 ± 0.68 (4) | 94.00 ± 1.86 (6)** | |
MMI + PTU | 105.51 ± 1.81 (6) | 98.90 ± 0.92 (6) | |
MMI + PTU + T3 | 101.30 ± 1.26 (6) | 93.32 ± 0.81 (6)** | |
Control | Cerebellum | 100.00 ± 1.64 (4) | 100.00 ± 0.40 (4) |
T3 | 97.58 ± 0.61 (6) | 100.14 ± 0.62 (6) | |
MMI + PTU | 97.86 ± 0.31 (5) | 101.60 ± 1.01 (6) | |
MMI + PTU + T3 | 95.2 ± 1.48 (6) | 100.29 ± 0.17 (6) |
Quantitive analysis of autoradiograms after in situhybridization for NSP and Oct-1 mRNA in the cortex, hippocampus, and cerebellum of thyroid hormone-manipulated adult rats. Values shown represent mean + SEM (n) of film density (converted to % controls ± CV) over the cortex, hippocampus, or cerebellum.
* Significantly different from control euthyroid rats receiving saline injections (p < 0.05).
** Significantly different from control euthyroid rats receiving saline injections (p < 0.01).
Subfields of Ammon's horn.