Fig. 5.

Recovery of cone-driven ERGs after a conditioning flash in WT, GRK1 −/−, and Arrestin −/− mice. White probe flashes isomerizing ∼1.2% of the M cone pigment and ∼0.09% of the UV cone pigment were delivered after a conditioning flash isomerizing ∼1% of the M and ∼0.06% of the UV pigment at ISIs specified in seconds to the left of the traces. Responses obtained without immediately preceding conditioning flashes are marked as Control. The upward pointing arrowsfor the bottommost traces in each panel show the time of the flash (a time gap of 3–5 msec containing a flash artifact has been omitted from some traces); the downward pointing arrows on the topmost traces indicate the times when the first four test flashes were delivered for the WT and Arrestin −/− mice.A, Recovery in WT mouse. The control record was obtained with an orange (λ > 530 nm) steady background that produced ∼6000 photoisomerizations rod⁻¹sec⁻¹, suppressing rod signals (Lyubarsky et al., 1999); for all other recordings, rod activity was suppressed with the conditioning flash. Each trace is the average of 10 records. B, Recovery in GRK1 −/− mouse; eachtrace is the average of five measurements. C, Recovery in Arrestin −/− mouse; each trace is the average of 15 records.