Fig. 2.

Functional GluR6 KARs in the mouse striatum.A, Inward current evoked by 500 nm domoate in a neuron recorded from the dorsal striatum of a wild-type mouse, in the presence of TTX (500 nm), dl-AP5 (50 μm), and picrotoxin (100 μm). In GluR6-deficient mice (GluR6−/−), higher concentrations of domoate are needed to activate an inward current in striatal neurons.B, Dose–response curves for low concentrations of domoate in the striatum of wild-type and GluR6-deficient mice. The amplitude of the inward current evoked by each concentration of domoate is represented in the y-axis (mean ± SEM,n = 3–11).