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. 2000 Mar 15;20(6):2175–2182. doi: 10.1523/JNEUROSCI.20-06-02175.2000

Fig. 8.

Fig. 8.

Effect of domoate on mIPSC frequency and amplitude in wild-type mice. Miniature IPSCs were recorded in the presence of TTX (400 nm), NBQX (1 μm), and APV (50 μm). A, Plot of mIPSC frequency versus time. The dotted line represents the average control value. Superimposed on the plot is the inward current evoked by activation of somatodendritic KARs present in the recorded neuron. Concomitant with this inward current, domoate (500 nm for 2 min) causes a moderate decrease in total mIPSC frequency.B–D, In the same neuron, a closer inspection of the effects of domoate on mIPSCs indicates that domoate mainly affects large-amplitude mIPSCs. B, Each mIPSC is represented by a vertical bar proportional to its amplitude to allow visualization of the activity over long recording periods (2 min).C, Amplitude distribution histogram of mIPSCs recorded over the same time period (3 min) in control conditions (open bars) and after application of domoate (filled bars). D, Cumulative amplitude histogram corresponding to the distributions shown in C for control conditions (dashed line) and after application of domoate (solid line).