Table 3.

Cell death as determined in situ by the TUNEL method

	PVE	IZ	CP
E16	0.65  ± 0.53	0.90  ± 0.85	0.40  ± 0.42
	n  = 2750	n  = 791	n  = 1980
E18
fh	18.61  ± 5.68	6.45  ± 3.70	9.83  ± 3.43
	n  = 1837	n  = 305	n  = 644
Normal	0.36  ± 0.63	0.63  ± 0.80	0.12  ± 0.27
	n  = 1459	n  = 480	n  = 835
P1
fh	*	10.32  ± 4.25	3.84  ± 2.63
		n  = 163	n  = 426
Normal	*	0.86  ± 0.89	0.21  ± 0.48
		n  = 479	n  = 470
P10
fh	*	**	2.21  ± 2.78
			n  = 215
Normal	*	**	1.91  ± 3.27
			n  = 450

The percentage of cell death was compared in the periventricular epithelium (PVE), intermediate zone (IZ), and cortical plate (CP). Counts of TUNEL-positive cells were taken from two to three sections from a representative brain of fh/fh and unaffected littermates at E18, P1, and P10. Further experiments supported these results. No difference in cell death was observed in a litter at E16, and cell death from representative brain is shown. nindicates the total number of cells counted. *By P1, the PVE has disappeared. **By P10, the IZ has disappeared.