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. 2000 Aug 1;20(15):5867–5873. doi: 10.1523/JNEUROSCI.20-15-05867.2000

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Copyright © 2000 Society for Neuroscience

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Fig. 5. — Effect of 8-OH DPAT at various CTs onPer1, Per2, and Per3expression in the hamster suprachiasmatic nucleus. RI in situ hybridization was performed for the quantitative analysis. Circadian expression of these genes was observed at (A) Per1 (ANOVA,F_(2,12) = 9.363,p = 0.0032), (B)Per2 (ANOVA, F_(2,13) = 62.375, p = 0.0001), and (C)Per3 (ANOVA,F_(2,13) = 39.892,p = 0.0001). 8-OH DPAT (5.0 mg/kg, i.p.) significantly reduced Per1(^#p < 0.005, Student'st test) and Per2(^∫∫p < 0.0001, Student'st test) but not Per3 mRNA levels 2 hr after drug injection at CT6. Numbers inparentheses indicate the number of experiments.