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. 2000 Aug 1;20(15):5709–5714. doi: 10.1523/JNEUROSCI.20-15-05709.2000

Fig. 1.

Fig. 1.

Effect of ibuprofen on IL-1β levels and GFAP levels in Tg2576 brains. A, B, IL-1β measurements. ANOVA analyses were performed on measurements in Tg− mice fed control diet (n = 5), Tg+ mice fed control diet (n = 8), and Tg+ mice fed ibuprofen (n = 9). A, Measurement of IL-1β levels in hippocampus and residual cortex in 16-month-old Tg+ and Tg− mice. IL-1β protein levels were measured in TBS-extracted supernatant fractions from Tg− mice fed control diet (open bar) and Tg+ mice fed control diet (hatched bar). Levels were significantly increased in both regions in Tg+ compared to Tg− animals. B, Effect of ibuprofen on IL-1β levels in Tg+ mice. IL-1β was decreased by 64.7% across all regions in ibuprofen-treated animals. Equality of variance was established with a logarithmic transformation. C, D, GFAP levels. C, Effect of transgene on GFAP levels. Semiquantitative measurements of GFAP were performed on immunoblots of Tg− and Tg+ animals fed control diet. A highly significant 51.7% elevation in Tg+ animals was found. D, Effect of ibuprofen on GFAP levels in Tg+ mice. Treatment with ibuprofen significantly decreased GFAP levels 20% across all regions in Tg+ animals. *p < 0.05. ***p < 0.001. Error bars indicate SE.