Fig. 2.
Long-lasting depression of inhibitory synapses in the LSO at a holding potential of −55 mV or less (voltage clamp).A, Representative recordings from a P10 LSO neuron show a maximum amplitude IPSC recorded at VHOLD = −80 mV at the beginning of the experiment (0 min) and its post-LFS depression at the end of the experiment (90 min). B, Long-lasting depression of IPSCs for all recorded LSO neurons at P7–P12 is shown. Means (± SEM) of IPSCs show that synaptic depression was significant after LFS (blackcircles). Age-matched control neurons that did not receive any LFS or intermediary MNTB stimulation (asterisks) did not get depressed. See Figure 6 for statistics.