Fig. 3.

Long-lasting depression of inhibitory synapses in the LSO at a holding potential of 0 mV. A, Long-lasting depression of inhibitory transmission for an individual P9 LSO neuron is shown. Top, Representative MNTB-evoked IPSCs are shown before (left) and after (right) LFS. Bottom, The amplitude of IPSCs in one neuron declined dramatically after LFS, and this depression persisted for 1 hr. B, Long-lasting depression of IPSCs for all recorded LSO neurons at P7–P12 is shown. Means (± SEM) of IPSCs show that synaptic depression was profound after LFS (blackcircles). Age-matched control neurons in which LFS was not delivered (whitecircles) or without LFS and intermediary MNTB stimulation (asterisks) displayed a smaller, but significant, decrease in amplitude.