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Amphetamine blocks LTD in VTA neurons.A, LTD was blocked in the presence of 1 μmamphetamine (horizontalbar) applied for 15 min before synaptic stimulation at 1 Hz for 6 min during depolarization to −40 mV. Insets, The averages of five EPSCs taken at the times indicated on the graph are shown. Calibration: 100 pA, 10 msec. B, The average of nine such experiments (6 identified dopamine neurons) is shown.
