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. 2000 Aug 1;20(15):5575–5580. doi: 10.1523/JNEUROSCI.20-15-05575.2000

Fig. 6.

Fig. 6.

Amphetamine does not block LTD at CA3-to-CA1 synapses in the hippocampus. A, Two independent afferent pathways in st. radiatum were stimulated alternately at 0.1 Hz while field EPSPs were recorded. At the arrows (top graph), stimulation to Pathway 2 was stopped, and LTD was induced in Pathway 1, using two trains of 1 Hz stimulation (see Materials and Methods). After induction of LTD in Pathway 1, 1 μm amphetamine was added to the bathing medium. Fifteen minutes later, stimulation toPathway 1 was stopped, and LTD-inducing stimuli were delivered to Pathway 2 (arrows inbottomgraph). Amphetamine had no effect on LTD induction or maintenance. B, Averaged experiments show that identical LTD was induced in hippocampal slices whether or not 1 μm amphetamine was included in the bathing solution [closedcircles, control solution (n = 4); opencircles, 1 μm amphetamine present for at least 10 min before 1 Hz stimulation (n = 5)]. Responses during the 1 Hz stimulation are omitted for clarity.