Fig. 4.

Effect of KW-6002 on locomotor activities of WT and D2R−/− mice. Horizontal (A) and vertical (B) movement of WT and D2R−/− mice in 10 min. After 1 hr habituation, mice were administered vehicle or KW-6002 (2.5 mg/kg), and their locomotor activities were counted for 5 min. Values represent sum of 5 min counting at 0 and 15 min after administration. *, p < 0.05, **, p < 0.01, ***, p < 0.001 versus WT vehicle-treated,^†, p < 0.05, ^†††,p < 0.001 versus vehicle-treated D2R−/− mice; Student's t test.