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Effect of KOR antisense and mismatch ODN treatment on EMD 61,753 modulation of visceral nociception. ODN-treated rats, previously tested with formalin, were deeply anesthetized and were examined electrophysiologically. EMD 61,753 dose-dependently inhibited the responses of the pelvic nerve afferent fibers to noxious colonic distension (80 mmHg, 30 sec). There were no differences in effects of the drug in antisense or mismatch ODN-treated rats.
