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. 2000 Aug 15;20(16):6077–6086. doi: 10.1523/JNEUROSCI.20-16-06077.2000

Fig. 6.

Fig. 6.

Innervation of rapsyn−/− and MuSK−/− muscle fibers by wild-type host axons. A, High-power photomicrograph showing the small bouton-like nerve terminal endings immunolabeled with antibodies against neurofilament and synaptophysin in rapsyn−/− mutants at P0. B, C, Several months (2.5 and 3 months for these grafts) after transplantation, normal host axons still only terminate in bouton-like endings without further maturating into the complex branching pattern of normal mature nerve terminals or nerve terminals innervating muscle fibers in the wild-type transplants (compare B, C with Fig. 4B1,C1).D, High-power photomicrograph showing the small bouton-like nerve terminal endings in MuSK−/− mutants at P0.E, F, Normal host axons innervating MuSK−/− muscle fibers still terminated in bouton-like endings after 4 months (compareE, F with Fig. 4B1,C1). Scale bar:A–E, 5 μm; F, 10 μm.