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. 2000 Aug 15;20(16):6063–6076. doi: 10.1523/JNEUROSCI.20-16-06063.2000

Fig. 7.

Fig. 7.

NPY colocalizes with NKX2.1 in the MGE proliferative zone of Dlx1/2 double mutants. A, D, G, Coronal sections through the caudal striatum of P0 pups showing NKX2.1 (A, D) and NPY immunoreactivity (G) in wild-type (A) andDlx1/2 double mutants (D, G). Periventricular neuronal ectopias express both NKX2.1 and NPY inDlx1/2 double mutants (stars in D, G, I, J). I, J, Higher magnification images of neuronal ectopias from the outlined boxed regions. The basal telencephalon of Dlx1/2mutants also contains cells that stain only for NPY (arrowhead in G, I) or NKX2.1 (SVZ* in D, J). B, C, E, F, Pregnant females received a single injection of BrdU at E10.5 (B, E) or E13.5 (C, F), and the location of labeled cells was analyzed at E19. Note that although the E10.5 injection results in a similar pattern of labeled cells in wild-type and Dlx1/2 mutant embryos, most of the cells labeled by the E13.5 injection in the mutant do not migrate to the mantle but remain within the periventricular region. The cells that accumulate in the mutant MGE* are positive for NKX2.1 (H, higher magnification of the regionoutlined in the boxed region inF). ac, Anterior commissure;Cx, cortex; ec, external capsule;FStr, fundus striatum; GP, globus pallidus; GP*, mutant GP; LGE, lateral ganglionic eminence; LGE*, mutant LGE;MGE, medial ganglionic eminence; MGE*, mutant MGE; SI, substantia innominata;Str, striatum; Str*, mutant striatum;SVZ, subventricular zone; SVZ*, mutant SVZ; VP, ventral pallidum. Scale bar: A, D, G–J, 150 μm; B, C, E, F, 200 μm.