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. 2000 Aug 15;20(16):6218–6224. doi: 10.1523/JNEUROSCI.20-16-06218.2000

Fig. 3.

Fig. 3.

Dose–response curves and mean SWD duration ± SEM for GABAAR antagonist-induced absence seizures in mGluR4−/− and mGluR4+/+ mice.A, The dose–response curve for GABAAR antagonist-induced absence seizures in mGluR4−/−and mGluR4+/+ mice (n = 10 for each group). The CD100 for pentylenetetrazole (PTZ), bicuculline (BMI), and picrotoxin (PXN) was 30, 3, and 1.5 mg/kg, respectively, in the mGluR4+/+ mice. The CD100 of PTZ for mGluR4+/+ mice failed to induce absence seizures in any mGluR4−/− mice. The CD100 of bicuculline and picrotoxin for mGluR4+/+ mice induced short-lived absence seizures in only 10% of mGluR4−/− mice that were tested. SEM was <10% for all data points and is not shown. ●, mGluR4+/+ (PXN); ♦, mGluR4+/+(BMI); ▪, mGluR4+/+ (PTZ); ▿, mGluR4−/− (PXN); ⋄, mGluR4−/− (BMI); ■, mGluR4−/− (PTZ). B, Mean SWD duration ± SEM for PTZ-induced absence seizures in mGluR4−/− and mGluR4+/+ mice (n = 10 for each group) that received 30 mg/kg of PTZ, the CD100 for mGluR4+/+ mice. The mGluR4−/− mice were completely resistant to absence seizures induced by low doses of this GABAAR antagonist. C, Mean SWD duration ± SEM in mGluR4−/− and mGluR4+/+ mice (n = 10 for each group) that received 3 mg/kg of bicuculline, the CD100 for mGluR4+/+mice. The SWD duration in the absence seizure induced by low-dose GABAAR antagonists was significantly (p < 0.001, ANOVA) shorter in the mGluR4−/− than in the mGluR4+/+mice. D, Mean SWD duration ± SEM in mGluR4−/− and mGluR4+/+ mice (n = 10 for each group) that received 1.5 mg/kg of picrotoxin, the CD100 for mGluR4+/+mice. The SWD duration in the absence seizures induced by low-dose GABAAR antagonists was significantly (p < 0.001, ANOVA) shorter in the mGluR4−/− than in the mGluR4+/+mice.