Table 2.
Similar affinities and densities for the A2AR agonist [3H]CGS 21680 in D2R+/+, D2R+/−, and D2R−/−mouse brain regions
| Mouse genotype | |||
|---|---|---|---|
| D2R+/+ | D2R+/− | D2R−/− | |
| Rostral striatum | |||
| LogKd | −7.61 ± 0.02 | −7.55 ± 0.04 | −7.62 ± 0.04 |
| Kd(nm) | 24.3 | 28.0 | 24.2 |
| Bmax (pmol/mg protein) | 1.92 ± 0.08 | 2.14 ± 0.17 | 1.63 ± 0.13 |
| Nucleus accumbens | |||
| LogKd | −7.66 ± 0.03 | −7.54 ± 0.02 | −7.58 ± 0.04 |
| Kd(nm) | 21.8 | 28.6 | 26.6 |
| Bmax (pmol/mg protein) | 1.44 ± 0.10 | 1.65 ± 0.11 | 1.37 ± 0.08 |
| Caudal striatum | |||
| LogKd | −7.58 ± 0.03 | −7.56 ± 0.04 | −7.54 ± 0.02 |
| Kd(nm) | 26.6 | 27.6 | 28.8 |
| Bmax (pmol/mg protein) | 2.17 ± 0.13 | 2.13 ± 0.13 | 2.11 ± 0.09 |
| Globus pallidus | |||
| LogKd | −7.63 ± 0.04 | −7.69 ± 0.05 | −7.51 ± 0.05 |
| Kd(nm) | 23.5 | 20.3 | 31.0 |
| Bmax (pmol/mg protein) | 0.62 ± 0.08 | 0.65 ± 0.16 | 0.70 ± 0.07 |
Mean values ± SEM are shown for n = 7–8 (D2R+/+), n = 6 (D2R+/−), and n = 8 (D2R−/−). Two-factor ANOVAs followed by Tukeypost hoc comparisons: Bmax,p < 0.05, for all brain region comparisons (except rostral vs caudal striatum).