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Arc antisense ODN treatment impairs the maintenance of LTP. The mean ± SEM change in EPSP amplitude measured immediately after LTP induction, at 4 hr, and then at 24 hr intervals for 5 d in the 18 rats that had stable data for both scrambled and antisense infusions. Note that there was no difference in LTP magnitude between treatments initially but that LTP decayed more rapidly in the Arc antisense ODN-treated hemispheres over subsequent days.
