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Plasmin effects on Aβ-induced chromatin condensation and fragmentation. Rat cortical neurons were treated with the indicated concentrations of Aβ for 48 hr in the presence or absence of plasmin (30 nm). Aβ induced chromatin condensation (Hoechst 33258 staining) and DNA fragmentation (TUNEL staining). These effects were largely reduced in cultures treated with plasmin and Aβ. These results are representative of those obtained in at least six separate neuronal preparations.
