Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Chronic antidepressant administration increases CREB phosphorylation in brain. Mice were administered saline, fluoxetine, or desipramine once daily for 14 d, and 6 hr after the last treatment phospho-CREB immunohistochemistry was conducted as described in Materials and Methods. Levels of phospho-CREB staining were scored, and results are presented as the mean ± SEM of four to six separate determinations. *p < 0.05 compared with saline (Kruskal–Wallis).
