Table 3.

Influence of chronic cocaine or haloperidol administration on CRE-mediated gene expression

	Phospho-CREB
	Saline	Cocaine	Haloperidol
Amygdala	0.0  ± 0.0	0.0  ± 0.0	0.4  ± 0.4
Cortex	0.3  ± 0.2	0.3  ± 0.3	0.4  ± 0.4
CA1	0.1  ± 0.4	0.0  ± 0.0	0.0  ± 0.0
CA3	0.1  ± 0.4	0.0  ± 0.0	0.2  ± 0.2
DG	0.2  ± 0.3	0.0  ± 0.0	0.2  ± 0.2
Hypothalamus	0.4  ± 0.2	0.3  ± 0.3	0.4  ± 0.4
Thalamus	0.3  ± 0.2	0.3  ± 0.3	0.8  ± 0.6

Vehicle, cocaine, or haloperidol was administered chronically for 14 d, and mice were killed 6 h after the last injection. Levels of β-galactosidase were determined by immunohistochemistry as described in Materials and Methods. The data are the mean ± SEM;n = 7 separate determinations.