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. 2000 May 15;20(10):3522–3528. doi: 10.1523/JNEUROSCI.20-10-03522.2000

Fig. 2.

Fig. 2.

Decrease in NMDA receptor activity during anoxia.A, Decrease in mean NMDA receptor open probability in cell-attached patches during 90 min of anoxia. Patch pipettes contained 10 μm NMDA. *p < 0.05 denotes significant decrease compared with normoxic control (Dunnett's test). Error bars show 1 SEM; n = 6–8 for each data point. B, Examples of [Ca2+]i changes produced by 100 μm NMDA (arrows) in cortical sheets in normoxic and anoxic conditions and after recovery from anoxia.C, Mean NMDA receptor activity (NMDA Δ Ca2+) in cortical sheets during anoxia and recovery.D, Example of the decrease in NMDA receptor activity observed during anoxia in dissociated cortical neurons. NMDA (100 μm) was applied for 10 sec periods.