Fig. 8.
hβ4 decreases Slowpoke activation rate but does not affect its deactivation rate. a, Normalized currents recorded at +80 mV from cells transfected with either hSlo and control vector, or hSlo and hβ4. b and c show time constants (τ) calculated from single exponential fits of current traces. b, Activation kinetics: hβ4 increases the activation time constant significantly (p < 0.001), whereas hβ1 is without effect (p> 0.05). c, Deactivation kinetics: hβ4 does not alter the deactivation time constant (p > 0.05), whereas hβ1 increases it significantly (p< 0.001). Recording conditions: detached inside-out patches, symmetrical K+ solutions, 1 μm free Ca2+ on the intracellular side, holding potential of −100 mV, steps to +80 mV.