Fig. 2.

Ionic basis of DHPG-induced current.A, Leak-subtracted I–V plot in normal K⁺ conditions in the presence and absence of DHPG (100 μm). B, SubtractedI–V plot representing DHPG-induced current alone, showing reversal potential of approximately −80 mV. C, Representative leak-subtracted I–V plot in the presence of potassium channel block and cesium. D, SubtractedI–V plot representing DHPG-induced current alone, showing reversal potential of −30 mV. E, Mean data ± SEM of DHPG-induced inward current amplitude (picoamperes) in voltage-clamp mode in normal potassium conditions, potassium block and cesium, and in the presence of cadmium (100 μm) (**p < 0.01).