Fig. 4.

Activation of group I mGluRs potentiates NMDA-evoked currents in STN neurons but has no effect on kainate-evoked currents. A, Representative voltage-clamp traces of NMDA-evoked currents in predrug, agonist, and wash conditions. Only the group I-selective agonist caused a reversible potentiation of NMDA-evoked currents. The group II and III agonists had no effect on NMDA-evoked currents. B, Mean data ± SEM of percent potentiation of NMDA-evoked currents by DHPG over predrug current amplitude. DHPG caused a significant potentiation compared with vehicle (*p < 0.05). C, Mean data ± SEM of percent predrug kainate-evoked current amplitude showing no difference compared with vehicle. D, Mean data ± SEM of percent potentiation of NMDAR currents by DHPG in normal K⁺ at −60 and −80 mV, cesium and potassium channel block at −60 mV, and in the presence of Cd²⁺ (100 μm).