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. 2000 Nov 1;20(21):7871–7879. doi: 10.1523/JNEUROSCI.20-21-07871.2000

Fig. 7.

Fig. 7.

mGluR5 mediates group I mGluR-evoked depolarization of STN neurons. A, Membrane potential traces showing depolarization with DHPG (100 μm), which is blocked by the mGluR5-selective antagonist MPEP (10 μm). Membrane depolarization is not blocked by the mGluR1-selective antagonist CPCCOEt (100 μm).B, Mean data ± SEM of change in membrane potential showing a significant inhibition of DHPG-mediated depolarization of STN neurons by MPEP (10 μm) compared with DHPG alone (**p < 0.001). MPEP also significantly blocks depolarization mediated by the mGluR5-selective agonist CBPG (100 μm) (*p < 0.05).