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mGluR5 mediates group I mGluR-induced potentiation of NMDA-evoked currents. A, Current traces of NMDA-evoked currents before, during, and after application of DHPG (100 μm). The potentiation is blocked by MPEP (10 μm) but not CPCCOEt (100 μm).B, Mean data ± SEM of percent potentiation of NMDA-evoked currents by DHPG over predrug conditions. MPEP (10 μm) significantly blocks potentiation of NMDA-evoked current compared with DHPG alone (*p < 0.05).
