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The effect of intrathecal SHU9119 (A), MTII (B), andd-Tyr-MTII (C) on withdrawal thresholds to von Frey stimulation in neuropathic rats. Thresholds are transformed to the logarithm of the applied force. Differences between postinjection and preinjection (baseline) values are plotted. Data are presented as mean ± SEM of 10 rats each, except 1.5 μg of SHU9119 (n = 4). *p < 0.05 versus vehicle; °p < 0.05 versus highest dose of MTII, d-Tyr-MTII, or SHU9119.
