Table 1.
Autoradiography of 125I-MPPI binding in 5-HTT mutant mice
| Density of125I-MPPI-labeled 5-HT1A receptors (fmol/mg tissue equivalent) | ||||||
|---|---|---|---|---|---|---|
| Female | Male | |||||
| 5-HTT +/+ | 5-HTT +/− | 5-HTT −/− | 5-HTT +/+ | 5-HTT +/− | 5-HTT −/− | |
| Frontal cortex | ||||||
| M2 I–IV | 43 ± 3 | 45 ± 3 | 39 ± 3 | 40 ± 4 | 45 ± 2 | 39 ± 2 |
| M2 V | 92 ± 6 | 100 ± 4 | 74 ± 10 | 101 ± 7 | 110 ± 3 | 105 ± 5 |
| M2 VI | 88 ± 6 | 94 ± 4 | 78 ± 14 | 89 ± 6 | 102 ± 4 | 100 ± 2 |
| LO I–IV | 66 ± 7 | 58 ± 5 | 67 ± 14 | 91 ± 11 | 93 ± 6 | 110 ± 7 |
| LO V | 142 ± 11 | 140 ± 6 | 128 ± 21 | 163 ± 11 | 159 ± 7 | 187 ± 4* |
| Septum | ||||||
| LSI | 110 ± 6 | 108 ± 6 | 77 ± 6* | 123 ± 13 | 126 ± 5 | 130 ± 16 |
| Ld | 230 ± 16 | 229 ± 13 | 165 ± 8* | 256 ± 16 | 260 ± 15 | 238 ± 19 |
| MS | 230 ± 19 | 241 ± 12 | 196 ± 24 | 278 ± 23 | 282 ± 25 | 302 ± 20 |
| Hypothalamus | ||||||
| PVN | 28 ± 3 | 29 ± 2 | 20 ± 1* | 40 ± 4 | 41 ± 4 | 38 ± 3 |
| AHN | 64 ± 2 | 70 ± 3 | 51 ± 2* | 73 ± 6 | 76 ± 5 | 65 ± 9 |
| LHN | 29 ± 2 | 32 ± 1 | 22 ± 3* | 31 ± 2 | 30 ± 2 | 26 ± 3 |
| VMN | 42 ± 3 | 39 ± 2 | 23 ± 5* | 69 ± 6 | 65 ± 3 | 60 ± 4 |
| DM | 45 ± 2 | 41 ± 1 | 27 ± 3* | 81 ± 4 | 75 ± 3 | 69 ± 6 |
| Amygdala | ||||||
| La | 29 ± 2 | 32 ± 3 | 24 ± 2 | 32 ± 2 | 30 ± 3 | 32 ± 2 |
| BLa | 30 ± 2 | 27 ± 2 | 23 ± 3 | 27 ± 1 | 27 ± 1 | 26 ± 2 |
| CeC | 41 ± 2 | 37 ± 2 | 28 ± 4* | 39 ± 2 | 41 ± 2 | 42 ± 5 |
| CeMAD | 130 ± 13 | 131 ± 10 | 98 ± 9 | 153 ± 21 | 144 ± 7 | 117 ± 3 |
| CeMAV | 90 ± 5 | 80 ± 5 | 58 ± 6* | 109 ± 14 | 105 ± 2 | 89 ± 7 |
| BMA | 150 ± 4 | 118 ± 11* | 89 ± 8* | 136 ± 14 | 141 ± 15 | 119 ± 14 |
| MeAD | 79 ± 3 | 79 ± 5 | 54 ± 2* | 87 ± 3 | 94 ± 5 | 73 ± 6 |
| Aco | 134 ± 5 | 128 ± 10 | 92 ± 2* | 136 ± 10 | 156 ± 16 | 120 ± 11 |
| Dorsal endopiriform | ||||||
| (DEn) | 327 ± 14 | 330 ± 19 | 261 ± 22* | 316 ± 18 | 317 ± 13 | 320 ± 16 |
| Hippocampus | ||||||
| CA1 | 300 ± 16 | 291 ± 21 | 322 ± 40 | 376 ± 21 | 362 ± 12 | 367 ± 19 |
| CA2 | 34 ± 2 | 30 ± 2 | 32 ± 3 | 81 ± 4 | 71 ± 4 | 70 ± 4 |
| CA3 | 41 ± 4 | 35 ± 2 | 43 ± 6 | 99 ± 6 | 83 ± 5 | 82 ± 4 |
| DG | 66 ± 15 | 46 ± 5 | 67 ± 19 | 170 ± 20 | 126 ± 10 | 107 ± 20 |
| Midbrain | ||||||
| DR | 677 ± 78 | 484 ± 63 | 257 ± 11* | 664 ± 57 | 573 ± 42 | 387 ± 43* |
| MR | 352 ± 30 | 353 ± 19 | 241 ± 26* | 374 ± 12 | 511 ± 34* | 315 ± 34 |
The data are represented as mean ± SEM of five to seven mice.
*
Significant difference from 5-HTT +/+ mice;p < 0.05.
The abbreviations are the same as listed in Figure 1. In addition,LO I–V, lateral orbital cortex layers I–V; M2 I–VI, secondary motor cortex layers I–VI.