Table 4.
8-OH-DPAT-stimulated 35S-GTP-γ-S binding in 5-HTT knock-out mice
| 35S-GTP-γ-S binding (fmol/mg tissue) | Ratio of125I-MPPI/35S-GTP-γ-S binding | |||||
|---|---|---|---|---|---|---|
| 5-HTT +/+ | 5-HTT +/− | 5-HTT −/− | 5-HTT +/+ | 5-HTT +/− | 5-HTT −/− | |
| Female | ||||||
| DRN | 128 ± 15 | 104 ± 14 | 78 ± 144-150 | 5.6 ± 0.6 | 5.3 ± 1.1 | 3.6 ± 0.5 |
| CA1 | 198 ± 15 | 180 ± 5 | 174 ± 11 | 1.6 ± 0.1 | 1.6 ± 0.1 | 1.8 ± 0.3 |
| Male | ||||||
| DRN | 89 ± 16 | 124 ± 13 | 81 ± 22 | 8.3 ± 1 | 4.2 ± 0.6 | 6.9 ± 2.4 |
| CA1 | 228 ± 14 | 227 ± 11 | 214 ± 17 | 1.7 ± 0.1 | 1.6 ± 0.1 | 1.7 ± 0.1 |
Data are represented as mean ± SEM of five to seven mice.
F4-150: Significant difference from 5-HTT +/+ mice;p < 0.05.
The abbreviations are as same as listed in Figure 1.