Table 1.
Apparent diffusion coefficient in the left (treated) and right (control) striatum
Time (hr) | ADC (×10−4 mm2/sec) | |||||
---|---|---|---|---|---|---|
Control | IL-1β | Neutrophil depletion and IL-1β | ||||
Left | Right | Left | Right | Left | Right | |
4 | 6.74 ± 0.82 | 6.96 ± 0.76 | ||||
5 | 6.63 ± 0.38 | 7.15 ± 0.56 | ||||
6 | 7.30 ± 0.25 | 7.29 ± 0.21 | 5.42 ± 0.35* | 7.35 ± 0.77 | 6.64 ± 0.34* | 7.49 ± 0.38 |
27 | 6.29 ± 0.35* | 7.14 ± 0.61 | 7.15 ± 0.58 | 7.28 ± 0.27 | ||
123 | 5.90 ± 0.70* | 7.10 ± 0.87 | 7.10 ± 0.26 | 7.13 ± 0.15 |
ADC, Apparent diffusion coefficient measured within a region of interest encompassing the striatum. Control, Injection of 1 μl of vehicle only into the left striatum. IL-1β, Pretreatment with anti-neutrophil serum to deplete animals of neutrophils followed by injection of 1 μl of IL-1β (1 ng/μl) into the left striatum.
Significantly different from control (right hemisphere) by paired t test at that time point (p< 0.05).