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RGS11 antagonized the effects of β5γ2. Increasing the ratio of RGS11 to γ2 reduced theIBa facilitation ratio produced by β5γ2 (A). However, RGS11 did not antagonize the effects of β2γ2 (B). In the second set of experiments (B), 8 μg of RGS11 was cotransfected with 1 μg of β2γ2 or β5γ2.Numbers of experiments are inparentheses. Data are plotted as mean ± SEM; *p < 0.01, unpaired t test between β5γ2 and β5γ2RGS11.
