Fig. 3.

Spatial reference (A) and working (B) memory formation in nonoperated control rats (n = 7) and rats that were continuously infused with BDNF antisense (n = 6) and sense oligonucleotides (n = 6) into the cerebral ventricle. The maze training was started 4 d after the start of continuous intracerebroventricular infusion of the oligonucleotide. Each value represents the mean ± SE. Antisense BDNF treatment significantly impaired reference (p < 0.001) and working memory formation (p < 0.001).