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Activation of hypocretin 1 receptors increases the firing rate of locus coeruleus neurons. Top tracing, Filtered recorded signal demonstrating the waveforms of the action potential. Calibration: 100 μV, 5 msec. Bottom, Rate meter record demonstrating that in situmicroelectrophoretic application of hypocretin 1 (1 mg/ml) produced a marked activation of a spontaneously active LC neuron. Calibration: 5 Hz, 5 sec.
