Table 1.

Pearson correlation coefficients for age-related changes in mRNA densities for NMDA subunits and densities of ligand binding to NMDA receptors

	10-month-old mice		30-month-old mice
	NMDA-displaceable [3H]glutamate	[3H]CPP	NMDA-displaceable [3H]glutamate	[3H]CPP
ζ1 mRNA	0.28	−0.18	0.05	0.58*
ɛ1 mRNA	−0.49	0.50	0.34	0.19
ɛ2 mRNA	0.22	−0.15	0.67*	−0.09
[3H]CPP	−0.18		−0.06

Means of the percentage of 3-month-old densities remaining in the 10- and 30-month-old mice across 17 individual brain regions were used to examine correlations.

*indicates p < .05.

n = 11–12 for NMDA-displaceable [³H]glutamate binding and all subunit mRNAs for 10-month-old mice.

n = 10–13 for NMDA-displaceable [³H]glutamate binding and all subunit mRNAs for 30-month-old mice. n = 6 for [³H]CPP for both age groups.