Fig. 5.

Anxiety levels in 6-month-old wild-type andApoe^−/− mice assessed in the elevated plus maze. Compared with the wild-type controls,Apoe^−/− mice showed reductions in the time spent in the open arms (A), in the distance moved in the open arms (B), and in the number of times they extended over the edges of the open arms to explore (C).Apoe^−/− mice also had abnormally increased plasma corticosterone levels after behavioral testing (D), consistent with increased anxiety. *p < 0.05 versus wild-type; n= 8 mice per group.