Fig. 9.
TRP perfusion produces a reversible reduction of the photoreceptor's light response. A, Light flashes (0.55 sec duration; log10 intensity = −2.0) were presented continuously at one flash/8 sec until a stable adaptation level was achieved. The sample labeled “0” is the average of 10 responses just before the onset of TRP perfusion (1.0 μl/min; 1.0 μm). The remaining four responses show the decline in the visual response between 1.0 and 5.0 min after the onset of perfusion. Each response is labeled with the time from perfusion onset to the beginning of the sample period. At the end of 5 min, the TRP perfusion was terminated, and after a 1.0 min hiatus, a saline wash was commenced. B, The 0 response is the average of the first five responses during the wash. The remaining records are averages of five successive responses beginning at the times indicated in minutes at the bottom of each trace.