Fig. 8.

5-HT innervation of the intermediate division of the nucleus accumbens. Neurotoxic effects of Meth (4 × 20 mg/kg) or PCA (2 × 10 mg/kg) on 5-HT-IR (A–C) and SERT-IR (D–F) axon terminals in the intermediate division of the nucleus accumbens are shown in dark-field images (interaural 11.2 mm). Thin, SERT-positive serotonergic axons predominate at this intermediate level of NAc (A, D). As in the rostral pole, most 5-HT axons in the intermediate division are lost after drug treatment. A small number of 5-HT axons are spared, and these are SERT-negative (B–F). Animals were killed 14 d after drug treatment, and adjacent sections were processed for 5-HT and SERT immunocytochemistry. A, D, Saline-treated; B, E, Meth-treated; C, F, PCA-treated. Scale bar, 300 μm. ac, anterior commissure; AcC, nucleus accumbens core;AcS, nucleus accumbens shell.