Fig. 2.

Alignment of the deduced amino acid sequence of netrin-G1a (7D5) with vertebrate netrins. Amino acid residues identical between netrin-G1a and other netrins are in black. Hydrophobic stretches (boxed) of netrin-G1a appear to be signals for secretion and for GPI linkage predicted by the ω and ω + 2 rules (Gerber et al., 1992; von Heijne, 1996), respectively. Thebrackets above the sequences indicate domain structures (domains VI, V-1, V-2, V-3, and C′) of netrin-G1a defined by homology with other netrins. Asterisks indicate the putative N-glycosylation sites of netrin-G1a. The nucleotide sequences of netrin-G1a and other isoforms have been submitted to the GenBank (accession numbers AB038662, AB038663, AB038664, AB038665, AB038666, and AB038667).