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Effect of bilateral infusion of muscimol (200 pmol in 220 nl) into the STN on the severity of seizures induced by intravenous bicuculline (0.35 mg/kg). Bilateral microinjection of muscimol or saline into the STN preceded seizure induction by 15 min. Means of the cumulative seizure score ± SEM are depicted.Asterisk indicates significant difference with respect to saline-microinjected controls (Mann–Whitney U;p < 0.05).
