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Well habituated mice: response to nicotine administration. Behavioral counts summed over 0–15, 20–35, and 40–55 min: sniffing (A), locomotion (B), rearing total (C), and sifting (D) responses to (−)-nicotine (0.1–2.7 mg/kg, s.c.) versus vehicle (V) in well habituated Wt (filled columns) and Hz (open columns). Data are means ± SEM forn = 8 per group. **p < 0.01, *p < 0.05 versus Wt.ap < 0.05,bp < 0.01,cp < 0.001 versus vehicle-treated mice of same genotype.
