Table 1.
Clinical and MS lesion data of patients included in NG2 and p75 studies
| Patients and disease category | Age/gender | Disease duration | Autolysis | Lesion number analyzed | Lesion activity | ||
|---|---|---|---|---|---|---|---|
| Active | Chronic active | Chronic inactive | |||||
| MS-1 SP | 53 /M | 22 years | 5 hr | 18 | 0 | 2 | 16 |
| MS-2 SP | 69 /F | 46 years | 4.5 hr | 4 | 0 | 0 | 4 |
| MS-3 RR | 43 /M | 9 months | 3 hr | 1 | 1 | 0 | 0 |
| MS-4 SP | 43 /M | 9 years | 7 hr | 3 | 0 | 1 | 2 |
| MS-5 PP | 32 /M | 10 months | 14 hr | 1 | 1 | 0 | 0 |
| MS-6 PP | 18 /F | 2 weeks | <24 hr | 10 | 4 | 6 | 0 |
| MS-7 SP | 56 /F | 26 years | 48 hr | 1 | 1 | 0 | 0 |
| MS-8 PP | 35 /F | 2 weeks | <24 hr | 4 | 0 | 4 | 0 |
| MS-9 PP | 29 /F | 5 years | <24 hr | 1 | 0 | 1 | 0 |
| MS-10 RR | 48 /F | 18 years | 35 hr | 3 | 0 | 2 | 1 |
| MS-11 PP | 36 /M | 4 years | <24 hr | 2 | 2 | 0 | 0 |
| MS-12 SP | 49 /F | 7 years | 6 hr | 7 | 4 | 3 | 0 |
| Total | 55 | 13 | 19 | 23 | |||
| Normal controls | |||||||
| Cardiac arrest | 52 /M | 16 hr | |||||
| Cardiac arrest | 91 /F | 9 hr | |||||
| OND* | |||||||
| SSPE | 8 /M | 2 years | 20 hr | ||||
| Epilepsy | 27 /F | 18 hr | |||||
| Devic's | 70 /F | 6 hr | |||||
| Primary CNS | 54 /M | 2 years | 6 hr | ||||
| Lymphoma | |||||||
SP, Secondary progressive, RR, relapsing/remitting, PP, primary progressive, * other neurological diseases.
In all, 55 lesions from 12 MS cases were analyzed. First five cases and all controls with short fixation time were studied for NG2 reactivity. All cases and controls were studied for p75 reactivity.