Fig. 2.

Inhibition of α-ketoglutarate dehydrogenase by H₂O₂. Nerve terminals were incubated in the absence (control) or presence of different concentrations of H₂O₂ for 5 or 10 min (a), or with 100 and 500 μmH₂O₂, respectively, for different lengths of time (b). In control samples the activity of α-KGDH was 14.2 ± 1.2 nmol · min⁻¹ · mg⁻¹taken as 100%. Data are the average ± SEM of eight determinations made in three independent experiments. *Significant compared with the control, p < 0.05.