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l-CCG LTD can be potentiated by Iso.A, Application of l-CCG (10 μm) induced an LTD. Twenty minutes after LTD stabilized, Iso (15 μm) was applied, which increased the synaptic strength back to the original level. B, Parallel experiments in which l-CCG and Iso were applied in the reverse order. Application of Iso (15 μm) induced an LTP.l-CCG (10 μm) application 20 min after the washout of Iso caused a complete reversal of LTP.
