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Glutamate release by brief titanic stimulation activates presynaptic mGluR II and induces LTD. In the presence ofd-APV (50 μm) and the glutamate uptake inhibitor trans-PDC (100 μm), brief titanic stimulation (100 Hz, 1 sec) evoked an LTD that was completely blocked by MCCG (100 μm). Inset shows the representative traces taken before and 60 min after the stimulation. Calibration: 10 mV, 40 msec.
