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Responses of GT1 neurons and model to addition of endoplasmic reticulum Ca2+-ATPase pump blocker thapsigargin (Tg). Simultaneous Vm(A) and [Ca2+]i(B) responses to 5 μm Tg in GT1 neurons. C–G, Model simulations of GnRH plus Tg response. Tg was simulated by setting the SERCA pump rates to zero. Calibration in A applies to A andB, and in C applies toC–G.
