Table 3.
Binding density of [125I]RTI-55 (femtomoles per milligram of tissue) in rat Acb and dorsal STR 3 d after a 5 d treatment with cocaine and/or the selective κ-opioid receptor agonist U-69593
| Treatment | Acbshell | Acbcore | Dorsal STR | n |
|---|---|---|---|---|
| Vehicle + saline | 18 ± 3 | 43 ± 7 | 70 ± 6 | 4 |
| U-69593 + saline | 13 ± 43-150 | 31 ± 73-150 | 52 ± 103-160 | 5 |
| Vehicle + cocaine | 23 ± 2 | 46 ± 1 | 66 ± 3 | 4 |
| U-69593 + cocaine | 14 ± 33-150 | 29 ± 63-150 | 49 ± 83-160 | 3 |
F3-150: p < 0.05 different from controls by two-way ANOVA (main effect of U-69593).
F3-160: p= 0.056 different from controls by two-way ANOVA (main effect of U-69593).