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Pretreatment with the selective 5-HT2Aantagonist MDL 100,907 completely blocks DOI-elicited Fos induction in the SSC. V-V, Animals pretreated with vehicle followed 30 min later by vehicle; V-DOI, vehicle-pretreated rats injected with DOI; MDL-V, pretreatment with MDL 100,907 with subsequent vehicle administration; MDL-DOI, pretreatment with MDL 100,907 followed 30 min later by administration of DOI. *p ≤ 0.0001 relative to V-V; **p≤ 0.001 relative to V-DOI.
